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Registro Completo |
Biblioteca(s): |
Embrapa Algodão. |
Data corrente: |
08/06/2011 |
Data da última atualização: |
16/11/2011 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
QUEIROGA, V. de P.; FREIRE, R. M. M.; ARAÚJO, M. E. R.; LIMA, V. I. de; QUEIROGA, D. A. N. |
Afiliação: |
VICENTE DE PAULA QUEIROGA, CNPA; ROSA MARIA MENDES FREIRE, CNPA; MARIA ELESSANDRA RODRIGUES ARAÚJO, CEULJI; VALDEMIR INÁRIO DE LIMA, UFPB; DIEGO ANTÔNIO NÓBREGA QUEIROGA. |
Título: |
Influência do tamanho da semente de amendoim sobre sua qualidade fisiológica. |
Ano de publicação: |
2011 |
Fonte/Imprenta: |
Agro@mbiente On-line, v. 5, n. 1, p. , jan./abr., 2011. |
ISSN: |
1982-8470 |
Idioma: |
Português |
Palavras-Chave: |
Classificação de semente; Teste de laboratório; Vigor da planta. |
Thesagro: |
Arachis Hypogaea. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00674naa a2200217 a 4500 001 1890896 005 2011-11-16 008 2011 bl uuuu u00u1 u #d 022 $a1982-8470 100 1 $aQUEIROGA, V. de P. 245 $aInfluência do tamanho da semente de amendoim sobre sua qualidade fisiológica.$h[electronic resource] 260 $c2011 650 $aArachis Hypogaea 653 $aClassificação de semente 653 $aTeste de laboratório 653 $aVigor da planta 700 1 $aFREIRE, R. M. M. 700 1 $aARAÚJO, M. E. R. 700 1 $aLIMA, V. I. de 700 1 $aQUEIROGA, D. A. N. 773 $tAgro@mbiente On-line$gv. 5, n. 1, p. , jan./abr., 2011.
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Embrapa Algodão (CNPA) |
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Registro Completo
Biblioteca(s): |
Embrapa Meio Ambiente. |
Data corrente: |
17/01/2017 |
Data da última atualização: |
02/03/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
BAPTISTA, R. C.; FERNANDES, M. A. M.; GILAVERTE, S.; QUEIROZ, S. C. do N. de; ASSALIN, M. R.; FERRACINI, V. L.; MONTEIRO, A. L. G.; REYES, F. G. R. |
Afiliação: |
RAFAELA DE CARVALHO BAPTISTA, FEA-UNICAMP; MARIA ANGELA MACHADO FERNANDES, LAPOC-UFPR; SUSANA GILAVERTE, LAPOC-UFPR; SONIA CLAUDIA DO N DE QUEIROZ, CNPMA; MARCIA REGINA ASSALIN, CNPMA; VERA LUCIA FERRACINI, CNPMA; ALDA LUCIA GOMES MONTEIRO, LAPOC-UFPR; FELIX GUILLERMO REYES REYES, FEA-UNICAMP. |
Título: |
Determination of moxidectin in serum by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study in lambs. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, Campinas, v. 28, n. 2, p. 250-256, 2017. |
Idioma: |
Inglês |
Conteúdo: |
Abstract: The widespread use of moxidectin (MOX), a parasiticide used in the sheep breeding, has induced the parasite resistance in Brazilian farms. As a consequence, the farmers often increase the dose and frequency of drug utilization, and disregards safety of meat or milk. In order to establish adequate therapeutic treatment it is necessary to know the pharmacokinetics of the drug in the animal's body. Thus, high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for the determination of MOX in serum lamb. Serum samples were treated with acetonitrile to precipitate proteins. A clean up by dispersive extraction in solid phase (SPE-d), using primary/secondary amine (PSA) and C18 sorbents, followed by freezing was performed. Method validation presented precision (coefficient of variation) and accuracy (recovery%) between 1.7-6.7 and 80.0-107.3%, respectively. The limit of quantification (LOQ) of the method was 2.0 ng mL-1 and a linear response was obtained over a range of 2.0 to 100 ng mL-1. This method was successfully applied to the determination of MOX in serum from suffolk lamb to evaluate the pharmacokinetic profile. |
Palavras-Chave: |
LC-MS/MS; Serum lamb. |
Thesagro: |
Análise de laboratório; Anti-helmíntico; Cordeiro; Cromatografia; Espectrometria; Soro Sangüíneo. |
Thesaurus NAL: |
Anthelmintics; Blood serum; Lambs; Liquid chromatography; Moxidectin; Pharmacokinetics; Tandem mass spectrometry; Veterinary drugs. |
Categoria do assunto: |
H Saúde e Patologia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/153417/1/2016AP13.pdf
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Marc: |
LEADER 02416naa a2200397 a 4500 001 2060930 005 2017-03-02 008 2017 bl uuuu u00u1 u #d 100 1 $aBAPTISTA, R. C. 245 $aDetermination of moxidectin in serum by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study in lambs.$h[electronic resource] 260 $c2017 520 $aAbstract: The widespread use of moxidectin (MOX), a parasiticide used in the sheep breeding, has induced the parasite resistance in Brazilian farms. As a consequence, the farmers often increase the dose and frequency of drug utilization, and disregards safety of meat or milk. In order to establish adequate therapeutic treatment it is necessary to know the pharmacokinetics of the drug in the animal's body. Thus, high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for the determination of MOX in serum lamb. Serum samples were treated with acetonitrile to precipitate proteins. A clean up by dispersive extraction in solid phase (SPE-d), using primary/secondary amine (PSA) and C18 sorbents, followed by freezing was performed. Method validation presented precision (coefficient of variation) and accuracy (recovery%) between 1.7-6.7 and 80.0-107.3%, respectively. The limit of quantification (LOQ) of the method was 2.0 ng mL-1 and a linear response was obtained over a range of 2.0 to 100 ng mL-1. This method was successfully applied to the determination of MOX in serum from suffolk lamb to evaluate the pharmacokinetic profile. 650 $aAnthelmintics 650 $aBlood serum 650 $aLambs 650 $aLiquid chromatography 650 $aMoxidectin 650 $aPharmacokinetics 650 $aTandem mass spectrometry 650 $aVeterinary drugs 650 $aAnálise de laboratório 650 $aAnti-helmíntico 650 $aCordeiro 650 $aCromatografia 650 $aEspectrometria 650 $aSoro Sangüíneo 653 $aLC-MS/MS 653 $aSerum lamb 700 1 $aFERNANDES, M. A. M. 700 1 $aGILAVERTE, S. 700 1 $aQUEIROZ, S. C. do N. de 700 1 $aASSALIN, M. R. 700 1 $aFERRACINI, V. L. 700 1 $aMONTEIRO, A. L. G. 700 1 $aREYES, F. G. R. 773 $tJournal of the Brazilian Chemical Society, Campinas$gv. 28, n. 2, p. 250-256, 2017.
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